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Biomarkers including fasting glucose, insulin resistance (HOMA-IR), and inflammatory markers (CRP, TNF-) provide baseline context for treatment selection and monitoring

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BRD4 is an epigenetic reader that regulates gene expression by forming a complex with the positive transcription elongation factor b (P-TEFb), promoting RNA polymerase II (Pol II), a mediator of DNA-dependent RNA synthesis (Jung et al., 2014)